Herpes Simplex Virus (HSV)
病毒编号 |
病毒名称 |
病毒颜色及用途 |
H01001 |
HSV-EGFP |
绿色,顺向跨多级 |
H01002 |
HSV-tdTomato |
红色,顺向跨多级 |
H02003 |
HSV-LSL-tdtomato-2a-TK(H356) |
红色,cre依赖,顺向跨多级 |
H03001 |
HSV-ΔTK-hUbC-tdTomato |
红色,不跨突触,与AAV-TK连用可实现顺向跨单级 |
H03002 |
HSV-ΔTK-LSL-tdTomato(H361) |
红色,不跨突触,cre依赖,与AAV-TK连用可实现顺向跨单级 |
参考文献
1. Bowers W J, Mastrangelo M A, Stanley H A, et al. HSV amplicon-mediated Abeta vaccination in Tg2576 mice:differential antigen-specific immune responses[J].Neurobiol Aging, 2005,26(4):393-407.
2. Frazer M E, Hyghes J E, Mas trangelo M A, et al. Reduced pathology and improved behavioral performance in Alzheimer’s disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4[J]. Mol Ther, 2008, 16(5):845-853.
3. Coen, D.M., Kosz-Vnenchak, M., Jacobson, J.G., Leib, D.A., Bogard, C.L., Schaffer, P.A., Tyler, K.L., and Knipe, D.M. (1989). Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.Proceedings of the National Academy of Sciences of the United States of America 86, 4736-4740.
4. Li, X., Chen, W., Pan, K., Li, H., Pang, P., Guo, Y., Shu, S., Cai, Y., Pei, L., Liu, D., et al. (2018). Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nature neuroscience 21, 1239-1250.
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