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Pharmacodynamic Evaluation

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Genevoyager has a professional team specialized in pharmacodynamic evaluation. With years of experience and a well-established pharmacology research platform, we can provide cell-based pharmacodynamic studies and in vivo pharmacodynamic studies using different disease models, tailored to customer needs. These services contribute to elucidating the mechanisms of pharmacodynamic effects and facilitating clinical translation research.


Services

In vivo pharmacodynamic evaluation

Genevoyager has established a comprehensive platform for constructing animal disease models, covering a wide range of diseases including neurological disorders, endocrine system disorders, respiratory/digestive system disorders, cardiovascular system disorders, rheumatic autoimmune diseases, and metabolic disorders. Detailed disease models are listed in the table below.


Category

Disease Models


Nervous System Diseases


Parkinson’s disease model

Alzheimer’s disease model
Aging and dementia models
Brain ischemia/hemorrhage/stroke model
Demyelinating disease model
Depression model
Epilepsy model
Anxiety model
Learning and memory model
Schizophrenia model
Pain disease model
Drug addiction model
Huntington’s disease model
Migraine model
Autism model
Spinal cord injury model
Amyotrophic lateral sclerosis (ALS) model


Endocrine System Diseases


DIO (diet-induced obesity) model

Metabolic liver disease model

DIO+STZ-induced T2MD model

Spontaneous diabetes model

Familial hypercholesterolemia model

B6-OB spontaneous obesity/diabetes model

LEPR gene knockout model

Multiple endocrine neoplasia model


Respiratory/Digestive System Diseases


Idiopathic pulmonary fibrosis model

Wilson Disease (WD) model

Non-alcoholic fatty liver disease (NAFLD) model

Gastric ulcer model

Intestinal motility model

Ulcerative colitis model


Cardiovascular System Diseases


Atherosclerosis model

Myocardial ischemia model

Aortic dissection model

Hypertension model

Heart failure model

Cardiac hypertrophy model


Rheumatic Autoimmune Diseases


Inflammatory bowel disease model

Rheumatoid arthritis model

Experimental autoimmune encephalomyelitis (EAE) model

Psoriasis model


Metabolic Diseases


Obesity model

Diabetes model

Non-alcoholic liver disease model

Alcoholic liver disease model

Hyperlipidemia model

Hyperuricemia model

Acute gout model

Sepsis model

Cholestasis model


Eye Diseases


Photoreceptor injury model

Chronic high intraocular pressure model

Acute retinal ganglion cell death model

Optic nerve crush injury model

Hypoxia-induced retinal neovascularization model

Laser-induced choroidal neovascularization model

Alkali burn-induced corneal neovascularization model

Age-related macular degeneration model


Ear Diseases


Transtympanic administration

Round window membrane intracochlear drug delivery


Urinary System/Kidney Diseases


Gentamicin-induced acute kidney injury model

Cisplatin-induced kidney disease model

Prostate hyperplasia model

Propionic acid-induced prostate model

Castration model

Renal fibrosis model

Renal failure model


Musculoskeletal Disorders


Arthritis model

Osteoporosis model


Tumor


Carcinoma in situ

Subcutaneously transplanted tumor

Hematologic tumor

CDX model


In vitro pharmacodynamic testing
Genevoyager provides in vitro pharmacodynamic testing services for various types of drugs, including nucleic acid and protein testing, cell autophagy assay, cell proliferation assay, cell apoptosis assay, cell motility assay, and other experiments or assays. Please refer to the table below for detailed testing projects.


Category

Testing Items


Nucleic Acid and Protein Testing


qPCR testing

WB testing

ELISA testing

RNA m6A methylation testing

IP testing

Co-IP testing


Cell Autophagy Assays


Electron microscopy observation of autophagosome formation

GFP-LC3 fusion protein tracing


Cell Proliferation Assays


ATP concentration assay

EdU / Brdu staining

Proliferation-related antigen detection

CCK-8 assay

Flow cytometry for cell cycle

MTT assay


Cell Apoptosis Assays


TUNEL staining

Flow cytometry for apoptosis

Caspase3 activity assay


Cell Motility Assays


TUNEL staining

Flow cytometry for apoptosis

Caspase3 activity assay


Other Experiments or Assays


Flow cytometry for apoptosis

Caspase3 activity assay

Flow cytometry for cell surface antigen detection

Mitochondrial membrane potential assay

Angiogenesis assay

Cell adhesion assay

Cell immunofluorescence detection

Oxidative stress assessment

Biochemical assay

Calcium ion concentration detection

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US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

ABOUT US TECHNOLOGY PLATFORM

US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

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