Single-dose toxicity

Repeated-dose toxicity: 7 days, 14 days, 28 days, 13 weeks, 26 weeks, 39 weeks

Species: mice, rats, beagle dogs, cynomolgus monkeys, rabbits, miniature pigs

Administration routes: oral, injection (intravenous/intraperitoneal/subcutaneous), dermal, ocular, etc.

Central nervous system (mice, rats)

Respiratory system (mice, rats, dogs, monkeys)

Cardiovascular system (dogs, monkeys)

hERG assay (in vitro)

Fertility and early embryonic development toxicity test (Phase I) (rats)

Embryo-fetal development toxicity test (Phase II) (rats, rabbits)

Perinatal toxicity test (Phase III) (rats)

Juvenile animal toxicity test (rats)

Ames test (in vitro)

Micronucleus test (in vitro/in vivo)

Chromosomal aberration test (in vitro)

Mouse lymphoma assay (in vitro)

Local irritation test (skin, blood vessels, eyes)

Sensitization test (active, passive)

Hemolytic test (in vitro)

In vitro phototoxicity test

Ophthalmic toxicity test

● Intracerebral injection

● Gastric administration

● Oral mucosal administration

● Nasal instillation

● Intrathecal administration

● Intrathoracic injection

● Intraperitoneal injection

● Subcutaneous injection

● Intradermal injection

● Intramuscular injection

● Transdermal administration

● Rectal administration

● Vaginal administration

● Intra-articular administration

● Infraorbital venous plexus administration

● Tail vein injection

● Intrathecal injection

● Intravitreal injection

● Subretinal administration