AAV-1.3×HBV-AAV Products-Spot product

The genome of hepatitis B virus (HBV) is a loose circular double-stranded DNA (RC DNA). The cccDNA is formed in the nucleus of the host cell as a transcription template to form the pre-genomic RNA (pgRNA) necessary for HBV amplification, which is then formed by reverse transcription in turn. Negative-strand DNA and DNA replication form double-stranded DNA to complete the amplification process of the viral genome.

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By taking advantage of the stable existence of AAV genome in host cells and the strong hepatophilicity of AAV type 8, we developed a series of rAAV-HBV1.3-mer WT replicon products carrying 1.3 copies to the full-length HBV genome. This series of products mimics the formation of pgRNA, which is closer to the natural life cycle of the virus and can steadily establish a long-term HBV infection and accelerate the anti-hepatitis B drug development process.

Product Information

1、 Customized services are available with abundant stock products labeled as D-ayw, C-adr, and B-adw. Our services include design, cloning, and ensure stable production.

2、 Applicable models: Chronic hepatitis B model, HBV persistent replication model, and can be used to study the replication mechanism of HBV and the R&D of anti-HBV drugs.

3、Available products are listed below.

Product List

Product Number	Product Name	Titer
PT-0717	rAAV8-1.3×HBV (D-ayw)	1.00E+12 vg/mL
PT-7350	rAAV8-1.3×HBV (C-adr)
PT-9245	rAAV8-1.3×HBV（B-adw，MT)
PT-9244	rAAV8-1.3×HBV（B-adw，AY)
PT-8804	rAAV8-1.3×HBV (gtF)

Note: Commonly used injection dosage and method: ≥1.00E+11 vg/mouse; tail vein injection.

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US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

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ABOUT US TECHNOLOGY PLATFORM

US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

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AAV-1.3×HBV

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Orbital Blood Collection in Mice

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