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AAV-1.2×HDV

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Hepatitis D Virus (HDV) is a circular, negative-strand RNA virus, its genome is approximately 1.7kb and has a double-stranded rod-shaped structure, the genome contains only one open reading frame (ORF) encoding hepatitis delta antigen (HDAg). HDV is a replication-defective virus that requires HBV surface protein (HBsAg) to complete the assembly of its own virus particles. Therefore, patients with HDV infection often have concurrent HBV infection.

Services

Genevoyager has developed a series of AAV products rAAV-1.2×HDV carrying 1.2 copies of the full-length HDV genome by taking advantage of the stable expression of AAV8 in host cells and strong hepatophilicity and combining a series of existing and self-developed (Patent No. CN111218446A) liver-specific promoters. This product can be used in combination with the AAV-HBV series to stably establish HBV/HDV co-infection and help the research of HDV replication mechanisms and the R&D of anti-HDV drugs.

Product Information

1、Customized services are available.

2、Applicable models: Chronic HBV/HDV co-infection model, can be used to study the mechanism of HDV replication and the development of anti-HDV drugs.

3、Available products are listed below.

Product List

Product Number

Product Name

Titer

PT-7497 rAAV8-Ath2-1.2×HDV (AG) 1.00E+12 vg/mL
PT-7499 rAAV8-Ath2-1.2×HDV (G)
PT-5700 rAAV8-APOE/AAT1-1.2×HDV(AG)
PT-5699 rAAV8-APOE/AAT1-1.2×HDV (G)
PT-4845 rAAV8-EAlb/hAAT-1.2×HDV (G)
PT-4844 rAAV8-EAlb/hAAT-1.2×HDV(AG)


Note:

(1) Commonly used injection dosage and method: ≥5.00E+10 HBV+5.00E+10 HDV vg/mouse; tail vein injection.

(2) The model needs to be used in combination with AAV-HBV virus to establish a model of HDV.

Application Cases

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US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

ABOUT US TECHNOLOGY PLATFORM

US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

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